We aimed to compare the efficacy and safety of HCQ and corticosteroid treatment in patients with Ig AN. Ninety-two patients with Ig AN who received HCQ in addition to routine renin-angiotensin-aldosterone system inhibitors (RAASi) therapy were included. Ninety-two matched historical controls who received corticosteroids were selected by propensity score matching. Baseline proteinuria levels were comparable between the HCQ and corticosteroid groups (1.7 [1.2, 2.3] vs. The percentage reduction in proteinuria at 6 months was smaller in the HCQ group than in the corticosteroid group (− 48.5% [− 62.6, − 31.4] vs. The time averaged proteinuria within the 6 months of observation was comparable for the HCQ and corticosteroid groups (1.1 [0.8, 1.5] vs. The cumulative frequency of patients with a 50% reduction in proteinuria during the study was also comparable between the two groups (52.2% vs. However, six of the 92 (6.5%) patients suffered from severe adverse events (SAEs) in the corticosteroid group, while no SAEs were observed in the HCQ group (6.5% vs. The antiproteinuric effect of HCQ might be slightly inferior to that of corticosteroids over 6 months in patients with Ig AN who were deemed to be candidates for HCQ and not corticosteroids treatment. Anti malarial medication hydroxychloroquine Chloroquine and aspirin Hydroxychloroquine rheumatoid arthritis Plaquenil good reviews Aug 22, 2008 Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. It is ment to get this undercontrol now and diminish your pain. Plaq is a longer time medication it may take two months before their is a noticable difference. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Ig A nephropathy (Ig AN) is the most prevalent type of primary glomerulonephritis worldwide . However, HCQ treatment was safer than corticosteroid treatment. Corticosteroids vs plaquenil Comparison of the effects of hydroxychloroquine and., Hydroxychloroquine Plaquenil Hydroxychloroquin and methotrexateAffects of stopping plaquenil Rheumatoid arthritis RA, the most common form of inflammatory arthritis, can lead to significant pain, disability, and deformity, and is a multisystem autoimmune disorder. steroid therapy has been shown to increase infection rates and impede wound healing. Plaquenil™, leflunomide Arava™, azathiaprine Imuran™, or. Perioperative Management of Medications Used in the.. Plaquenil vs. Rheumatrex, Trexall Prescription Treatment for Rheumatoid.. Plaquenil vs Prednisone Comparison -. There are three main antimalarial drugs are prescribed for lupus symptoms. Here are the three most common antimalarial drugs prescribed for lupus Hydroxychloroquine Plaquenil This is the most commonly prescribed antimalarial because it is generally believed to cause fewer side effects than the others. Lbs or less - up to 200 mg Plaquenil daily; A lupus patient explains her changes in vision. Ann Utterback, 67, a broadcast voice specialist who lives in Gaithersburg, Md. was diagnosed with lupus in 2005. She says she’s always been extra-sensitive to medications, and her vision loss is related to both corticosteroids and Plaquenil. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower.