In fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph,” says Ann S. Hydroxychloroquine not working what next Plaquenil and ibuprofen together Plaquenil and flu shot Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Jun 11, 2013 I have been on plaquenil for almost 3 years now and it gave me back my life! I was diagnosed with UCTD at first but rheumy is starting to believe that it's primary sjogrens. My joint pain is under control and mild at times. The fatigue almost gone! However rheumy says plaquenil does not target the specific symptoms of dry eyes and dry mouth. During my last visit, I told him I was struggling with fatigue, so he prescribed Plaquenil hydroxychloroquine. Plaquenil is an antimalarial medication that is also commonly prescribed for a variety of chronic illnesses. I take it to help combat fatigue, and the difference it makes is pleasantly surprising. “I had been very active my whole life, and the fatigue just knocked me flat. Utterback, Ph D, a broadcast voice specialist in Virginia who was diagnosed with lupus in 2006. Plaquenil and fatigue Experiences taking Plaquenil for Fatigue and Muscle Pain., Study Raises Questions about Sjogren's and Plaquenil Can plaquenil be used to treat fibromyalgia Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. Is lethargy and tiredness a side effect of hydroxychloroquine?. Things that Changed My Life with Lupus Fatigue, Part 3. Strategies for managing fatigue Lupus Foundation of America. Plaquenil has been a life-saving drug for me, quite literally. I was a mess in 2004-2005 and then a dr put me on Plaquenil, and in 3 weeks most of my symptoms had disappeared. I had pain all. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. I am 99% sure that the Plaquenil has not caused your fatigue. If anything, it’s Lupus OR psychosomatic. Plaquenil is a slow-acting drug which is why you take it long term. It honestly takes on average 1 to 3 months to work and be built up in your system, which is why you typically have a 3-6 month review after being prescribed it.