Additionally, another exception occurred while executing the custom error page for the first exception. Chloroquine and hydroxychloroquine belong to the quinolone family. Best way to take plaquenil Available doses of hydroxychloroquine Aralen dosage malaria prevention Atp quantification assay chloroquine Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter. The mechanism of chloroquine and hydroxychloroquine toxicity is not well understood. Chloroquine has an affinity for pigmented melanin-containing structures, which may explain its toxic properties in the eye. Melanin serves as a free-radical stabilizer and can bind toxins, including retinotoxic drugs. Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. The image below depicts hydroxychloroquine retinopathy. Fluorescein angiogram of left macula in patient with hydroxychloroquine retinopathy. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. Chloroquine toxicity in eye Early Plaquenil Toxicity Detected without Bull’s Eye., Chloroquine and Hydroxychloroquine Toxicity Practice. Plaquenil and toradolPlaquenil and myasthenia gravisChloroquine fas associated This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine DermNet NZ. Chloroquine and HydroxyChloroquine Toxicity ROQUE Eye.. The mechanism of toxicity is unknown but is thought to be due to accumulation of the medication in the retinal pigment epithelium RPE, leading to subsequent RPE degeneration. 1 Because of this theorized accumulation, hydroxychloroquine toxicity can progress despite cessation of the medication. 1,2 Color photograph of left eye documenting end-stage chloroquine retinal toxicity, with disc pallor, vascular attenuation, diffuse pigment mottling, and pigment deposition along the peripheral retinal vessels similar to retinitis pigmentosa. Visual acuity was 20/200. He had received oral chloroquine 150 mg per day for 6 months duration 27 g cumulative dose 12 years ago. The drug was discontinued at the onset of bull’s eye maculopathy in both the eyes. Despite early cessation of the drug the maculopathy progressed leading to consecutive optic atrophy.