Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. What is in chloroquine How does plaquenil affect lichen planus Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. We’ll show you photos to help you identify your. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. Systemic lupus erythematosus; treatment; disease activity; We thank Drs Figueroa-Parra et al for their interest in our paper1 and their comment regarding the value of chloroquine CQ as an alternative antimalarial in systemic lupus erythematosus SLE.2 As the authors point out, there are data, mostly for older studies, to support the efficacy of CQ in SLE.3 Nevertheless, over the last 20. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Chloroquine lupus erythematosus Treatment of Systemic Lupus Erythematosus An Update., Chloroquine Side Effects Common, Severe, Long Term. Hydroxychloroquine 200 mg good rxPlaquenil cause alopeciaAraleneChloroquine and aspirin Exacerbations of bipolar disorder triggered by chloroquine in systemic lupus erythematosus—a case report. J Bogaczewicz, T Sobów, A Bogaczewicz, E Robak, P Bienkowski, A Sysa-Jędrzejowska, and A Woźniacka. Lupus 2013 23 2, 188-193 Download Citation. Exacerbations of bipolar disorder triggered by chloroquine.. Chloroquine as alternative antimalarial in systemic lupus.. Early Diagnosis and Treatment of Discoid Lupus Erythematosus. Chloroquine phosphate is used occasionally to decrease the symptoms of rheumatoid arthritis and to treat systemic and discoid lupus erythematosus, scleroderma, pemphigus, lichen planus, polymyositis, sarcoidosis, and porphyria cutanea tarda. Talk to your doctor about the possible risks of using this drug for your condition. Chloroquine is a synthetic antimalarial medication that was first developed in 1934. In addition to its antimalarial effects, chloroquine has been used extensively in rheumatology and dermatology since the 1950s. Discoid lupus erythematosus. Reticular erythematous mucinosis. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis.