Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects. Bowman nodules hydroxychloroquine Plaquenil toxicity optos Hydroxychloroquine metabolism Chloroquine and pancreatic cancer Saposin D is released together with three other similar proteins, saposins A, B and C, from a common precursor called prosaposin 1-5precursor is proteolytically processed into mature saposins in late endosomes and lysosomes. Genetic defects of saposins have provided insights into their role in the degradation of sphingolipids. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Shamin and colleagues investigate whether the LTP Saposin B directly binds to CD1d molecules for lipid antigen loading. It is known from the literature - well quoted in the manuscript - that Saposin B is the main regulator of CD1d-lipid antigen presentation to iNKT cells but to date it is not clear whether the two proteins directly interact. While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. Saposin b binds chloroquine RCSB PDB - 4V2O Structure of saposin B in complex with., Chloroquine Indications, Side Effects, Warnings - Why chloroquine over other medicationsPlaquenil worksRheumatoid arthritis choosing initial treatment plaquenil vs enbrel Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The Lysosomal Protein Saposin B Binds Chloroquine — [email protected] The lipid transfer protein Saposin B. Wellcome Open Research. Robert Doyle - College of Arts & Sciences at Syracuse University. The front cover picture shows the binding of the antimalarial drug chloroquine by the lysosomal protein saposin B. Chloroquine is a lysosomotropic drug with toxicity associated with prolonged use. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. About. My previous research experiences focused on Metal-citrate transport in K. radiotolerans, investigating the binding of human Saposin B to antimalarial drugs, the total synthesis of 8,16.