Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil dosage weight Rheumatoid arthritis methotrexate therapy hydroxychloroquine monotherapy May 07, 2019 Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. The many mechanisms for the hypoglycemic effects of antimalarials 10. These properties have demonstrated clinical efficacy in noninsu-lin-dependent patients, including those refrac-tory to sulfonylureas 11. Lupus patients benefit from these properties as well. In the Hopkins lupus cohort, for example, treatment with MECHANISM OF ACTION. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. SUMMARY OF EVIDENCE in development Ponticelli C et al. 2017 “Hydroxychloroquine in systemic lupus erythematosus SLE” Expert Opin Drug Saf. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil lupus mechanism Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert, Antimalarials in systemic lupus erythematosus benefits. Botox and plaquenilPlaquenil in australiaPlaquenil 400 mg daily costAutofluorescence plaquenil toxicity Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus. Arthritis Rheum 2006; 84. UpToDate. Hydroxychloroquine Plaquenil RheumTutor. Hydroxychloroquine - Wikipedia. Hydroxychloroquine in systemic lupus erythematosus SLE Ponticelli C 1 and Moroni G 2 1 MD, Senior Consultant Nephrological Unit, Humanitas Clinical and Research Center, Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Systemic lupus erythematosus SLE, also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary between people and may be mild to severe. Common symptoms include painful and swollen joints, fever.