It is very famous (for its effectiveness) rather infamous (for its characteristic bitter taste), I still remember during my childhood back in India, elders used to threaten kids that if they won’t sleep in bed equipped with mosquito nets, they would have to eat chloroquine, and all kids out of fear for chloroquine rather malaria itself, would immediately agree to go to bed under the net (which they otherwise did not like normally). Anyways, in last few decades because of emerging chloroquine-resistant malaria parasites, chloroquine was almost forgotten and researchers started to look for other more effective and less toxic drugs to treat and prevent malaria. Chloroquine drug interactions Chloroquine readymade sigma Interactions between flecainide and hydroxychloroquine Chloroquine malarone Aug 19, 2014 Where and How Chloroquine Fights Cancer. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Qunine and Chloroquine Interestingly, it has been recently reported in the Nature magazine that the antimalaria drug Quinine that is also known to have anti cancer actions its derivative chloroquine has strong anti cancer effects as well interferes with serotonin biosynthesis and action Ref. I just checked some older studies and it. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. Autophagy (from Greek auto-oneself, phagy-to eat) is a process of self-cannibalization which is dependent on the presence of autophagosomes, autolysosomes, as well as an intact nucleus in the cell. It is only last couple of years that chloroquine got sudden attention especially among biologists when cancer biologists noticed its role as an inhibitor of autophagy. Chloroquine ovarian cancer Chloroquine Sigma-Aldrich, Serotonin Makes Tumors Happy Too - Cancer Treatments - from. Hydroxychloroquine brandHydroxychloroquine widely usedCan hydroxychloroquine affect graves diseaseSide effects of hydroxychloroquin Chloroquine, which targets autophagy, has been tried in cancer trials. Ironically, it was used in tumors with very high autophagy levels, the exact opposite of ovarian cancer. Autophagy genes act as tumor suppressors in ovarian cancer. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Chloroquine reduces hypercoagulability in pancreatic cancer.. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The autophagy inhibitor chloroquine, which functions at the late stage of autophagy, significantly reduced resveratrol-induced cell death and caspase 3 activity in human ovarian cancer cells. We also demonstrated that targeting ATG5 by siRNA also suppressed resveratrol-induced apoptotic cell death. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Maycotte P1, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases.