The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Is plaquenil used to treat osteoarthritis Plaquenil visual field defects Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Aug 15, 2012 Lumbar canal stenosis also is associated with leg cramps.13 Nerve damage from cancer treatment may be a cause of legs cramps, with a small study demonstrating that leg cramps were present in 82. QUOTE=DawnI have been on plaquenil for around 8 months or so but these leg cramps have just gotten worse and the ladies I work with told me to get calcium with magnesium. That would help out with the leg cramps but I am worried with all the meds that I take I am afraid that it might interact with the meds. Medications that are strongly associated with leg cramps include intravenous iron sucrose, conjugated estrogens, raloxifene, naproxen, and teriparatide. Nocturnal leg cramps are associated with vascular disease, lumbar canal stenosis, cirrhosis, hemodialysis, pregnancy, and other medical conditions. Plaquenil leg cramps Hydroxychloroquine Sulfate Muscle Spasms Reports - DrugInformer, Nocturnal Leg Cramps - American Family Physician Plaquenil tablets 200mg I've gradually have become sensitive to dairy but the last few days, it all but kills me. I've been on Plaquenil for almost 2 wks now and I'm also taking Prednisone, could one of these be causing my extreme stomach cramps? 2 nights ago, I had a cheeseburger and mac and cheese and I thought I was going to die about 1 in the morning. Plaquenil and stomach issues." Lupus Community - Support.. Foot and leg cramps Arthritis Information. PLAQUENIL Side Effects, Reviews by Patients -. Plaquenil “ Side Effects Dizzy, upset stomach, back pain and side pain, abdominal cramps, leg cramps, rapid heart rate, anxiety and body felt covered in bruises Before taking Plaquenil my only symptom. Oct 24, 2013 After just 4 days on Plaquenil, I had severe stomach cramps, no appetite, GERD pain, diarrhea and a migraine. Not sure that the migraine was related but it happened on day 4. After contacting my Rheumatologist, I was told to stop taking the drug. Apr 28, 2009 And, as far as Plaquenil and eye problems, the Ophthamologists I've talked to including a Neuro Ophthalmologist say that while Plaquenil can cause serious damage to the optic nerve, it's very rare. Annual appointments with an ophthalmologist are important in order to catch any problems early.