Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Surveillance ophtalmologique plaquenil sciencedirect Prescription et surveillance du plaquenil au pdf What is hydroxychloroquine sulfate tablets used to treat Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times. Accumulation of the drug may result in deposits that can lead to blurred vision and blindness. A retrospective study was carried out, over a twelve year period, of all cases of acute chloroquine poisoning where more than 2 g of chloroquine had been taken. It included 386 patients; of these, 60 who had taken drugs other than chloroquine, and 17 who had ingested less than 1 g of the drug, were excluded. Jul 03, 1993 Don Michael TA, Aiwazzadeh S. The effects of acute chloroquine poisoning with special reference to the heart. Am Heart J. 1970 Jun; 79 6831–842. Gustafsson LL, Walker O, Alván G, Beermann B, Estevez F, Gleisner L, Lindström B, Sjöqvist F. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Acute chloroquine poisoning Epidemiologic Notes and Reports Childhood Chloroquine., Chloroquine C18H26ClN3 - PubChem Does chloroquine interact with vitamins We did not find a meaningful correlation between the amount ingested as estimated by history and the peak blood chloroquine concentration; the latter was highly correlated with the mortality rate. CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. Treatment of acute chloroquine poisoning a 5-year experience.. Chloroquine poisoning. Rapidly fatal without treatment.. Chloroquine - FDA prescribing information, side effects.. Jul 30, 2019 The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. One hundred sixty-seven consecutive patients with acute chloroquine overdose admitted to our toxicology ICU. The mean amount ingested by history was 4.5 +2- 2.8 g. and 43 26% of 167 patients ingested 5 g. The mean blood chloroquine concentration on admission was 20.5 +/- 13.4 mumol/L. Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss.