In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine hydroxyzine interaxtion Plaquenil slows lupus On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Oct 12, 2019 Looking for subtle retinal changes. Hydroxychloroquine is commonly used to treat autoimmune inflammatory diseases such as rheumatoid arthritis. A rare side effect is retinal toxicity, which can cause irreversible and progressive vision loss. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal changes with the use of hydroxychloroquine Ocular Disease Monitoring Critical to Avoid Retinal Toxicity., Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil sickle cellHydroxychloroquine buyChloroquine-induced pigmentation The greatest concern people with lupus have when taking hydroxychloroquine is related to vision and an increase in risk for retinal damage. A new investigation analyzed the retinal changes over a five-year period in people with lupus and did not find clinically relevant retinal changes in the group. The study concludes that hydroxychloroquine therapy is safe for long-term use at doses 5 mg/kg/day. Safety of Long term use of Hydroxychloroquine Therapy Further.. Novel Image Analysis Platform May Detect Early Signs of.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, and other inflammatory and dermatologic conditions. Retinal toxicity from HCQ, and its analog, chloroquine, has been recognized for many years.2,3 By some estimates, in the United. Purpose To characterize functional and structural changes in hydroxychloroquine HCQ retinal toxicity after drug cessation. Methods Twenty-two patients 91% female; mean age 58.7 ± 11.4 years; mean duration of HCQ treatment 161.1 ± 90 months; mean dose 5.9 ± 1.9 mg/kg with detected HCQ retinopathy were monitored for 6 months to 82 months after HCQ cessation with multimodal imaging. Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3.