Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can you breastfeed while on plaquenil Plaquenil and anthrax vaccine Plaquenil knee weakness Tlr7 hydroxychloroquine ic50 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. Hydroxychloroquine ocular toxicity includes keratopathy, ciliary body involvement, lens opacities, and retinopathy. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Ocular toxicity hydroxychloroquine Ocular Toxicity of Hydroxychloroquine Request PDF, Chloroquine And Hydroxychloroquine Toxicity - Abstract. Colordx plaquenil toxicity Hydroxychloroquine HCQ is efficacious for various diseases1,2, but can produce “bulls-eye” retinopathy that decreases vision even after discontinuance3,4. Retinopathy can be present in 7.5% of patients after 5 or more years of HCQ treatment, increasing to 20% after 20 years2. Hydroxychloroquine Ocular Toxicity Lessons Learned The.. Ocular toxicity of hydroxychloroquine - HKMJ. Plaquenil Risk Calculators. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Clinical research has resulted in precise screening protocols and safe dosing guidelines to prevent ocular toxicity and detect retinal damage at an early stage. Etiology Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea.