I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Cellulitis of leg and plaquenil Plaquenil and thrombocytopenia Plaquenil screening review of optometry I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. If you aren’t responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine called triple therapy or adding a biologic drug such as etanercept Enbrel, adalimumab Humira, or infliximab Remicade. Learn about drug interactions between hydroxychloroquine oral and methotrexate sodium oral and use the RxList drug interaction checker to check drug combinations. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Methotrexate and hydroxychloroquine Hydroxychloroquine Uses, Dosage & Side Effects -, Common Questions About Taking Methotrexate for Rheumatoid Arthritis Plaquenil and biaxin for lyme diseaseChloroquine syrup brand name I know Plaquenil has helped me a ton, because I tried going off of it once to see if I really needed it. The first two weeks weren't bad, as Plaquenil has a high half-life and there was still some Plaquenil in my body. After that, my Lupus got progressively worse until I gave up and re-started the Plaquenil after 6 weeks of being off it. Methotrexate vs. Plaquenil - Autoimmune diseases - Inspire. Hydroxychloroquine oral and methotrexate sodium oral Drug.. Combination therapy with methotrexate and hydroxychloroquine.. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate is a type of disease-modifying anti-rheumatic drug DMARD. It’s used to reduce activity of the immune system for people who have certain conditions. The immune system normally protects the body from infections or bacteria by causing inflammation to fight them. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in.