My husband has been taking Plaquenil (generic hydroxychloroquine) for almost 2 yrs., under a rheumatologist's care. He became very ill, and was diagnosed w/ viral meningial encephalitis. We were much later told that the Plaquenil had "lowered his tolerance to infection, as it is also an immuno-suppressant." In essence, the medicine allowed the viral infection to cross the barrier between his brain and blood/lungs. Can you take potassium supplements while on plaquenil 400 mg hydroxychloroquine Aug 02, 2010 1. Yes, Plaquenil suppresses the immune system. Autoimmune disease such as Sjogrens occurs when the body gets "confused" and attacks healthy tissue instead of just attacking the germs. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. From a technical point of view plaquenil is an immunosuppressant, however, from a medical point of view it is definitely NOT considered as one as its action is so light as to be insignificant in that respect. Cellcept may also cause a reduction in the number of certain cells in your blood. A reduction in your white blood cell count could increase your chance of infection. As with other immunosuppressive medications, it is important that you try to avoid infection and notify your doctor at the first sign of illness. (He was never told of that risk when he was put on the medication.) Added : What I failed to mention (above) is that he almost died in April when this happened. His/our question is as to whether he can or should EVER go back on the medication and risk exposure to further illnesses if it is true that Plaquenil or the generic for is, in fact, an immuno-suppressant and presents a serious health risk for him? Plaquenil immunosuppressive therapy Medications for Sjogren’s Syndrome NYU Langone Health, Is plaquenil an immunosuppresant? Lupus Forums at The. Chloroquine is aChloroquine allergyCan sulfasalazine and plaquenil be taken together The number of patients taking immunosuppressive drugs for the management of autoimmune inflammatory conditions is increasing. The general practitioner needs to be active in preventing, monitoring and managing the adverse effects of these drugs even long after the treatment has ceased. Long-term management of patients taking immunosuppressive.. Treating Lupus with Immunosuppressive Medications Johns.. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Sarcoidosis, the most common indications for therapy are ocular and lung disease. Although experience is limited, it should be considered as an alternative for patients who can-not tolerate methotrexate. It is recommended for the first three months of therapy patients have monthly CBCs. For patients who experience severe toxicity from leflunomide, Cyclophosphamide Cytoxan® is a potent immunosuppressive agent that is reserved for severe cases of refractory rheumatoid arthritis and those with manifestations such as vasculitis. It is used in the treatment of other autoimmune conditions including lupus and vasculitis. Published evidence says that it is mediated by T-lymphocytes. Plaquenil is an anti-inflammatory drug approved by the FDA for malaria, lupus erythematosus, and rheumatoid arthritis. It has an effect on T-lymphocyte mediated inflammation, making it a logical choice for a treatment trail for alopecia areata.