Chloroquine dosing for lupus retina

Discussion in 'Generic Chloroquine' started by Gabarjoba, 23-Feb-2020.

  1. Agatta New Member

    Chloroquine dosing for lupus retina


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine has a particularly high affinity for melanin -containing cells and hence there are very high levels of chloroquine in the skin mainly, the epidermis and retina. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine dosing for lupus retina

    Recommendations on Screening for Chloroquine and., Chloroquine MedlinePlus Drug Information

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  4. Chloroquine dose as off-label use in Lupus erythematosus It is not considered as a first-line agent due to the potential retinal toxicity. The daily dose should not exceed 2.3 mg/kg/day.

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    Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease Mar 15, 2019 The first reports of retinal toxicity attributed to chloroquine appeared during the late 1950s. In 1958, Cambiaggi first described the classic retinal pigment changes in a patient receiving chloroquine for systemic lupus erythematous SLE. Sep 15, 2014 Specifically, a daily dose of 6.5mg/kg based on ideal body weight and a cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine are both considered risk factors for retinal toxicity. Therefore, lower daily doses do not necessarily preclude patients from developing toxicity due to the risk from cumulative dosage.

     
  5. 1kov Guest

    Benefits include even better soft lens searches and helpful contact lens calculators (including RGPs and cross cylinders). Retinal Physician - Hydroxychloroquine Maculopathy An. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk. Conditions Plaquenil-related Eye Problems Eugene Eye Care
     
  6. kostich XenForo Moderator

    Hydroxychloroquine Oral Uses, Side Effects, Interactions, Pictures. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

    Plaquenil Dosage Guide - - Prescription Drug.