Hydroxychloroquine retinopathy pathogenesis

Discussion in 'Health Canada Drug Database' started by qwertypad, 17-Mar-2020.

  1. Greenrow New Member

    Hydroxychloroquine retinopathy pathogenesis


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    Early detection of hydroxychloroquine-induced retinopathy is known to prevent visual acuity loss and serious progression after the therapy is stopped, and these data suggest that screening should. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology 2011;15. 17. Browning DJ, Lee C. The relative sensitivity and specificity of 10-2 visual fields, multifocal electroretinography, and spectral domain optical coherence tomography in detecting hydroxychloroquine and chloroquine retinopathy. Plaquenil or hydroxychloroquine is under the quinolone family. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects.

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    Hydroxychloroquine retinopathy pathogenesis

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  5. In the United States, hydroxychloroquine is the antimalarial drug of choice because of its low retinal toxicity. 1 – 4 Between 19, only 47 cases of hydroxychloroquine retinopathy have been reported in the peer-reviewed literature. 5 Despite the existence of unreported cases, hydroxychloroquine retinopathy is rare.

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    Sir, We agreed with the conclusions of Latasiewicz et al 1 ‘Hydroxychloroquine retinopathy an emerging problem’, which cited cases of hydroxychloroquine HCQ-induced retinal damage. Three patients had received 400 mg HCQ daily for over 15 years equaling 4.93 mg/kg/day in two and 5.6 mg/kg/day in one and all developed maculopathies of varying severity. Retinopathy is the major concern others are more common but benign. The incidence of true hydroxychloroquine retinopathy is exceedingly low; less than 50 cases have been reported. Although its pathogenesis is unclear, risk factors include daily dosage of hydroxychloroquine, cumulative dosage, duration of treatment, coexisting renal or liver disease, patient age, and concomitant retinal disease. Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy.

     
  6. Baalooo Well-Known Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. RA and Hydroxychloroquine How Effective is it for Rheumatoid Arthritis. Recommendations on Screening for Chloroquine and Hydroxychloroquine. How Safe Is Long-Term Hydroxychloroquine?
     
  7. sharap742007 New Member

    CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG Chloroquine Phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug.

    Chloroquine Phosphate - WebMD
     
  8. SKrai Well-Known Member

    Fatal Chloroquine Poisoning A Rare Cause of Sudden Cardiac. Massive Chloroquine Poisoning is Highly Fatal—Colin Phipps et al Fatal Chloroquine Poisoning A Rare Cause of Sudden Cardiac Arrest electrocardiogram ECG showed sinus tachycardia of 102 beats/minute with a QT interval QTC of 372 ms. Potassium levels were corrected overnight with 120 mmol/L of IV potassium.

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures.