Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Plaquenil and ibuprofen interaction Chloroquine cryptocaryon Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Plaquenil and weight loss. Hollywood8687 02/27/2014. I recently went on Plaquenil a few months ago, and I have been noticing how much weight I've been losing. I feel like I am losing too much weight. I am a thin person, and I am sick very often. Last week, I lost three pounds, and the week before I lost two pounds. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Hydroxychloroquine side effects weight loss Hydroxychloroquine Side Effects - GoodRx, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine step 1 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Plaquenil and weight loss DailyStrength. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects.. Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. The more common side effects that can occur with hydroxychloroquine include headache. dizziness. diarrhea. stomach cramps. vomiting. Approximately 23% of the treated patients showed abnormal weight gain P = 0.001. Patients treated with doxycycline and hydroxychloroquine presented significantly lower concentrations of Bacteroidetes P = 0.002, Firmicutes P = 0.01, and Lactobacillus P = 0.02.