I have had horrible trouble every time I taper prednisone and have had to go down 1mg per week or two. BTW I saw the post on hair loss and I also have significant bald patches on temples and thickening itchy scalp by them. Hugs to all the lupies tonight, Jessi Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. But this time I have been able to go from 15 to 12.5 for 2-3 days then down to 10mg in another 2-3 days!!!! I hope you can get off of it completely, or at least take a small maintenance dose. Plaquenil for scleroderma Plaquenil medication Plaquenil indications Plaquenil and cbd oil Plaquenil is an anti-malarial that slows the progression of the disease. Prednisone is a cortiocosteriod that manages inflammation. They have different jobs to do and don't interfere with each other. By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. I have been on prednisone for 15 months and am down to 5 mg. I cannot seem to get below that dose without having a flate. My rheumatologist has started me on Plaquenil and has said this should help me get off the prednisone. He said he would rather see me on Plaquenil instead of prednisone due to less side effects of the Plaquenil. It's a good sign that your inflammation is going down. Also, I have had a rash on my chest for years and it is suddenly a lot better--alot. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Prednisone and plaquenil Prednisone/Plaquenil question -, Plaquenil and Prednisone Plaquenil for raynaud' Hi there, Just curious if anyone else has had severe constipation from these drugs. I had rectal surgery 4 months ago and am still recovering and finding it difficult with the constipation from these meds. I am on Prednisone 10 mgs, plaquenil 400mgs a day, folgard b12, b6 folic acid ca supplement, diclofenac 75 mgs Immune & Autoimmune - Lupus Prednisone, plaquenil and. Plaquenil? I have been on prednisone for 15 months. - PMRGCAuk. Plaquenil, prednisone DailyStrength. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Brand names for prednisone include Deltasone, Rayos, and Prednisone Intensol. Plaquenil and belong to different drug classes. Plaquenil is an antimalarial medication and prednisone is a glucocorticoid. Side effects of Plaquenil and prednisone that are similar include nausea, vomiting, or headache. Summary Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly.