PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. For radical cure of The recommended adult dosage is 200 to 400 mg (155 to 310 mg base) daily, administered as a single daily dose or in two divided doses. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. What does plaquenil do for autoimmune diseases Withdrawal from hydroxychloroquine Hydroxychloroquine metabolism cyp Antimalarial therapy such as hydroxychloroquine in systemic lupus erythematosus SLE has documented benefit for reducing disease activity, improving survival, and reducing the risk of SLE-related thrombosis and myocardial infarction. This content is excerpted from MKSAP 17 with permission from the American College of Physicians ACP. Use is. How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. Hydroxychloroquine has the benefits of reducing cholesterol levels, a modest anti-platelet effect and it may reduce the extent of permanent tissue injury in lupus. Hydroxychloroquine appears to be safe in pregnancy. The addition of mepacrine 50-100mg daily may be useful in those not responding to hydroxychloroquine alone. In a small percentage of patients, side effects may require temporary reduction of the initial dosage. 400 mg to 600 mg (310 to 465 mg base) daily, administered as a single daily dose or in two divided doses. Therapeautic dose of plaquenil for lupus Plaquenil Hydroxychloroquine MyLupusTeam, Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Plaquenil drugbank Term or high-dosage 4-aminoquinoline therapy for discoid and systemic lupus erythematosus, or rheumatoid arthritis. Retinopathy has been reported to be dose-related. When prolonged therapy with any Antimalarial compound is contemplated, initial base line and periodic every three months ophthalmologic examinations including visual acuity, PLAQUENIL®. Drug Therapy of Lupus - LUPUS UK. Safety of Long term use of Hydroxychloroquine Therapy Further.. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day. Regarding hydroxychloroquine levels and lupus activity, Costedoat- Chalumeau et al 24 measured whole blood levels in 143 individuals taking a standard dose of 400 mg per day and found a lower hydroxychloroquine level in those with active disease and that lower baseline levels were predictive of disease flare. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.