Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Aps plaquenil Plaquenil increases sugar levels Folic acid may also help with many of the other common side effects from methotrexate, such as fatigue, headaches, hair loss, and oral ulcers. Ask your doctor if folic acid might help you -- don't. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Background 34 year old mother of 2 diagnosed in December with RA high RF and Anti-CCP. I'm on methotrexate injections just recently increased to 20 mg and plaquenil 200 mg twice a day. And folic acid. Early December I received a steroid injection to help with the pain/inflammation and improve my mobility temporarily. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma., Compare Plaquenil vs Methotrexate - Chloroquine phosphate malaria side effectsBpi nite burn and hydroxychloroquineHow many hours does plaquenil work in the bodyChloroquine sensitiveWho owns plaquenil Some patients complain of headache, fatigue, and feeling “wiped out” also called methotrexate “fog”. These side effects can often be overcome by increasing folic acid or using an activated form of folic acid known as folinic acid leukovorin® given as a 5mg dose 12 hours and sometimes 24 hours after methotrexate is given. Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center. Side effects plaquenil/methotrexate. rheumatoid. Methotrexate vs Plaquenil Comparison -. Methotrexate is a potent folic acid antagonist and so many doctors prescribe folic acid to help with the side effects of methotrexate, such as nausea. But she has MTHFR and folic acid is toxic for her, hence he switched her to the methylated version, L-5-Methylfolate. Side effects can develop if the methylfolate dose is too high. Folic acid and folinic acid are forms of vitamin B9, which you need to keep your cells dividing and growing normally. Folic acid is also essential in the production of red blood cells. Methotrexate blocks some of the actions of folic acid, which can lead to side effects such as mouth sores, abdominal pain, liver problems, hair loss, and anemia. Low dosages of Methotrexate Rheumatrex, such as 7.5 mg given orally once per week, are extremely effective in the treatment of lupus. Methotrexate can be given orally drops mixed with water or by subcutaneous injection once a week. It is now standard practice to use folic acid to counter some of the minor side effects of Methotrexate.