I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Chloroquine phosphate eye drops Inj chloroquine dose Find user ratings and reviews for Plaquenil oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction. See what your medical symptoms. Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination. We evaluated the long-term effectiveness of maintaining treatment with hydroxychloroquine sulphate HCQ to prevent major flares in quiescent SLE. Forty-seven patients with quiescent SLE who had been randomized to take HCQ n = 25 or placebo n = 22 as part of a 24-week withdrawal trial were evaluated for an additional 3 years. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Withdrawal symptoms of plaquenil Withdrawal syndrome in Plaquenil how severe and when it., Taking Plaquenil for Rheumatoid Arthritis Plaquenil monitoring guidelinesStopping plaquenil for surgeryDoes plaquenil reduce painPlaquenil and neutropenia Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. A Long-Term Study of Hydroxychloroquine Withdrawal on.. A Randomized Study of the Effect of Withdrawing.. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. May 15, 2015 It would be unlikely IMO that the Plaquenil is the cause, since there is tapering necessary when stopping it and no documented 'withdrawal' syndrome associated with it. If you have taken it for a long time, it is probably not even out of your system yet, since Plaquenil has a half-life of 30-60 DAYS not hours. Plaquenil didn't work for me after 4 months of 200mg per day. When it was put up to 400mg daily it eventually worked after about another two and a half months. My rheumy suggested that I stop it for a month every year to give the body a rest.