Chloroquine malaria mechanism of action

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  1. Sokol72 Moderator

    Chloroquine malaria mechanism of action


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

    Plaquenil and ibd Chloroquine hemozoin

    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. Chloroquine is still the drug of choice for sensitive malaria parasites although ACTs are used increasingly. Chloroquine is therefore used widely for P. vivax, P. malariae and P. ovale, but except in a very few areas has been replaced for P. falciparum treatment. The time-honoured oral chloroquine regimen of 25 mg base/kg spread over 3 days 10, 10, 5 or 10, 5, 5, 5 mg/kg at 24-hour intervals can be condensed into 36 hours of drug administration.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine malaria mechanism of action

    Chloroquine – howMed, Chloroquine Mode of Action Science

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  3. In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive.

    • Antimalarial Drug Mechanism of Action What is Chloroquine..
    • Chloroquine - an overview ScienceDirect Topics.
    • Antimalarial drugs Mode of action and status of resistance.

    Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. These 3Hquinoline compounds became associated with hemozoin. But, the effectiveness of chloroquine against Plasmodium falciparum has declined as resistant strains of the parasite evolved. This study explains malaria origin and presents Plasmodium evolution and chloroquine mode of action on parasite. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using chloroquine while you are pregnant. Preventing malaria

     
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    Reliable administration and reading of the TST requires standardization of procedures, training, supervision, and practice. Screening for tuberculosis infection prior to initiation of anti-TNF. Update--TB therapy and plaquenil Plaquenil hydroxychloroquine sulfate Drug / Medicine Information
     
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    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses