Hydroxychloroquine autophagy inhibitor

Discussion in 'Plaquenil' started by lebed_2000, 16-Mar-2020.

  1. Roman Krakov XenForo Moderator

    Hydroxychloroquine autophagy inhibitor


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Rangwala, R. et al. Combined MTOR and autophagy inhibition phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. Autophagy 10, 1391–1402 2014. Hydroxychloroquine HCQ is a lysosomotropic autophagy inhibitor being used in over 50 clinical trials either alone or in combination with chemotherapy. Pharmacokinetic PK and pharmacodynamic PD studies with HCQ have shown that drug exposure in the blood does not correlate with autophagy inhibition in either peripheral blood mononuclear cells or tumor tissue. To better explain this PK/PD. Hydroxychloroquine HCQ is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Hydroxychloroquine autophagy inhibitor

    Hydroxychloroquine sulfate Autophagy inhibitor, Hydroxychloroquine A Physiologically-Based Pharmacokinetic.

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  6. Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor TLR 7/9.

    • Hydroxychloroquine Sulfate Autophagy inhibitor Read..
    • Hydroxychloroquine HCQ, Autophagy and TLR9 Inhibitor..
    • Combined MTOR and autophagy inhibition Phase I trial of..

    Autophagy inhibition remains a very attractive strategy to augment standard therapy and improve long-term outcomes for a broad range of malignancies. Our collective work, to date, has demonstrated that we are finally on a strategic trajectory to move beyond HCQ with respect to clinical autophagy inhibition. Jun 01, 2018 e21138 Background A potential resistance mechanism to chemotherapy in NSCLC is through activation of cell survival pathways such as autophagy. Studies in genetically engineered mouse models demonstrate that autophagy inhibition suppresses lung tumor development and progression, especially in Kras mutated tumors. We report safety and efficacy of adding an autophagy inhibitor. Hydroxychloroquine can be combined with other agents in renal or other solid cancers to augment autophagy inhibition as an anti-cancer mechanism. Abstract. Purpose. Everolimus inhibits the mechanistic target of rapamycin mTOR, activating cytoprotective autophagy. Hydroxychloroquine HCQ inhibits autophagy. Based on

     
  7. 4auHuK Guest

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Plaquenil Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  8. brt XenForo Moderator

    Suppression: 400 mg (310 mg base) orally on the same day every week Comments: -Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart). Plaquenil Side Effects on Your Eyes and Vision Hydroxychloroquine retinopathy Eye Despite Plaquenil dosing recommendations, retinal toxicity.
     
  9. qsin User

    Safety of Long term use of Hydroxychloroquine Therapy Further Verified. Safety of Long term use of Hydroxychloroquine Therapy Further Verified for People with Lupus Hydroxychloroquine Plaquenil® was approved by the Food and Drug Administration for symptoms of lupus. The greatest concern people with lupus have when taking hydroxychloroquine is related to vision and an increase in risk for retinal damage.

    Plaquenil Side Effects on Your Eyes and Vision
     
  10. borisgrom XenForo Moderator

    Hydroxychloroquine Oral Uses, Side Effects, Interactions. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage.

    Generic Plaquenil Availability -