Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Dosage of chloroquin forvivax malaria Hydroxychloroquine causing rash where Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. In the 1940's chloroquine and related antimalarials were subjected to extensive pharmacologic and clinical investigations. 1-6 However, the dosage of chloroquine required to treat an acute attack of malaria or for prolonged suppressive therapy was small in comparison to the accumulated chloroquine dose attained in patients in the past decade in the treatment of chronic diseases such as rheumatoid arthritis, discoid lupus, and systemic lupus erythematosus. 7 Recently, numerous reports have. The mechanism of chloroquine and hydroxychloroquine toxicity is not well understood. Chloroquine has an affinity for pigmented melanin-containing structures, which may explain its toxic properties in the eye. Melanin serves as a free-radical stabilizer and can bind toxins, including retinotoxic drugs. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Acute chloroquine toxicity Hydroxchloroquine and Chloroquine Toxicity, Histopathology of Chloroquine Retinal Toxicity JAMA. Did plaquenil work for youPlaquenil and eye painDoes plaquenil interact with alcoholWhat do hydroxychloroquine doIs there an ed treatment when taking plaquenil One cannot assume that twice the chloroquine doses would be toxic for hydroxychloroquine. Chloroquine overdoses cause serious rapid symptomatology, with symptoms frequently seen within 30 minutes. Death is usually within 1 to 3 hours of ingestion and the cause is cardiac arrest. Treatment of hydroxychloroquine overdose - ScienceDirect. Chloroquine and Hydroxychloroquine Toxicity Practice.. Chloroquine toxicity -. Chloroquine CQ and hydroxychloroquine HCQ are anti‐rheumatic medications frequently used in the treatment of connective tissue disorders. We present the case of a 45‐year‐old woman with CQ‐induced cardiomyopathy leading to severe heart failure. Chloroquine/hydroxychloroquie has a well-studied toxicity profile. The half-century-long use of this drug in the therapy of malaria demonstrates the safety of acute administration of chloroquine to human beings. None. One hundred sixty-seven consecutive patients with acute chloroquine overdose admitted to our toxicology ICU. The mean amount ingested by history was 4.5 +2- 2.8 g. and 43 26% of 167 patients ingested 5 g. The mean blood chloroquine concentration on admission was 20.5 +/- 13.4.