Chloroquine volume of distribution

Discussion in 'Reliable Pharmacy' started by HotBaby, 27-Feb-2020.

  1. motodor XenForo Moderator

    Chloroquine volume of distribution


    If you believe Wordfence should be allowing you access to this site, please let them know using the steps below so they can investigate why this is happening. , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    Large volume of distribution 50 L/kg; Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45 If the drug distributes into all body water the volume of distribution would increase to approximately = 0.57 l/kg If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is chloroquine which has a = 250-302 l/kg Both hydroxychloroquine and chloroquine have a large volume distribution and a long half-life, consistent with their slow onset of action and prolonged effects after drug discontinuation.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Chloroquine volume of distribution

    Drug Distribution to Tissues - Clinical Pharmacology - Merck., Volume of distribution - Wikipedia

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  6. Chloroquine is extensively distributed with an enormous total apparent volume of distribution Vd more than 100 L/kg, and a terminal elimination half-life of 1 to 2 months. As a consequence, distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria.

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    A metabolite of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. In the group of healthy subjects the range was 550‐2,200 ng ml‐1. Values for terminal elimination rate constant, lambda z plasma clearance CL, initial volume of distribution V1 and volume of distribution at steady state Vss were calculated. Chloroquine 15000L Shows highly lipophilic molecules which sequester into total body fat. Vd rarely corresponds to a real volume & thus also called APPARENT volume of distribution. Approx physiological volumes for a 70 kg man Plasma~3 L

     
  7. Vindovs Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Plaquenil - FDA prescribing information, side effects and uses
     
  8. zzz! Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Sjögrens Fatigue – an Autoimmune Conundrum! SjögrensLife Plaquenil and Depression/Anxiety - Symptoms and Medical. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.
     
  9. Vatanius User

    CHLOROQUINE PHOSPHATE TABLETS BP 250MG WHAT ARE CHLOROQUINE PHOSPHATE TABLETS BP 250 MG? These tablets are white, round biconvex tablets with a breakline on one face. The active ingredient is Chloroquine Phosphate BP 250 mg. Each tablet also contains the inactive ingredients Lactose BP, Starch BP, Sodium Starch Glycollate BP, Magnesium Stearate BP and Stearic Acid BP.

    Drug - Chloroquine Phosphate-250 mg 250mg - 10 Tablets Tablet.
     
  10. malin_ka Well-Known Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More The dosage is based on body weight. 6.5 mg/kg maximum dose 400 mg should be given on the same day each week starting 2 weeks before exposure to malaria.

    Will you have Weight loss with Hydroxychloroquine sulfate.