See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Cyclosporine and plaquenil Uronema chloroquine phosphate Chloroquine walgreens Apo hydroxychloroquine 200 mg Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Methotrexate side effects - Arthritis Information, Hydroxychloroquine Oral Route Side Effects - Mayo Clinic What is plaquenil side effectsPlaquenil dilated eye retinal examWhat happens if i stop taking plaquenilPlaquenil related diseasesChloroquine retinopathy dose Too many side effects of both methotrexate and Hydrochloroquine prompted my beautiful daughter to encourage me to go on a strict diet with no meds. I did check with my gp and rheumy re this. I am now thank God in remission 🌸 Does anyone take methotrexate and hydroxychloroquine. - NRAS. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Arthritis Board Index Methotrexate vs plaquenil side effects.. Methotrexate is contraindicated in pre-existing liver conditions; making it necessary to notify your doctor of any pre-existing liver problems. Liver complications and even liver failure are possible long-term side effects of the drug. If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious sometimes fatal side effects, such as lung problems, lung infections Pneumocystis jiroveci pneumonia, skin reactions, diarrhea, and mouth sores ulcerative stomatitis. See also Side Effects section. Aug 27, 2013 I saw him three weeks ago, and he encouraged me to try to taper down now that the plaquenil is helping so much. According to him, only doses lower than 3 mg per day can be considered to have zero long-term side effects, so he either wants me off the steroids completely, or to get at or below 3 mg.